N-Methylaniline → HCID 67850432, compound

HRID 1198111Notes

Reaction equation

HRID 1198111 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:10]=[C:11]([Cl:18])[C:12]3[S:17][CH:16]=[CH:15][C:13]=3[N:14]=2)=[C:4]([CH3:19])[CH:3]=1.[CH3:20][NH:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>C(OCC)C>[ClH:18].[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[N:10]=[C:11]([N:21]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH3:20])[C:12]3[S:17][CH:16]=[CH:15][C:13]=3[N:14]=2)=[C:4]([CH3:19])[CH:3]=1

Participants

4

Reactant 2

HCID 7515N-MethylanilineHCID 10402158HCID 10402158, compound

Product 1

HCID 67850432HCID 67850432, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

2-(4-Fluoro-2-methylphenylamino)-4-chlorothieno-[3,2-d]pyrimidine (1.5 g, 0.0051 mol) and N-methylaniline were heated in an oil bath at 150° for 1 hour. Addition of diethyl ether gave a solid which was collected by filtration and dried, (1.85 g). Recrystallization from ethanol gave the title compound, (0.75 g), m.p. 242°-244°.

Workup

  1. customgave a solid which
  2. filtrationwas collected by filtration
  3. customdried
  4. customRecrystallization from ethanol

Sources & evidence

ORD record
ord-81653044044c49bca64944bb6ad6eb0b
Source dataset
uspto-grants-1994_01
Patent number
US05280026

Reaction notes

Loading…