HCID 54311543, compound → HCID 23184155, compound

Participants

Reaction Steps

A mixture of tetraethyl 4-phenoxybutylaminomethylenebisphosphonate (1.37 g) and concentrated hydrochloric acid (20 ml) was heated for two hours under reflux. The reaction mixture was concentrated under reduced pressure. The concentrate was treated with water to give 4-phenoxybutylaminomethylenebisphosphonic acid (0.549 g, 53%), m.p. 206° C. to 208° C.

Provenance & Evidence