HCID 54311543, compound → HCID 23184155, compound

HRID 1198120Notes

Reaction equation

HRID 1198120 reaction equation
[O:1]([CH2:8][CH2:9][CH2:10][CH2:11][NH:12][CH:13]([P:22](=[O:29])([O:26]CC)[O:23]CC)[P:14](=[O:21])([O:18]CC)[O:15]CC)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>Cl>[O:1]([CH2:8][CH2:9][CH2:10][CH2:11][NH:12][CH:13]([P:22](=[O:23])([OH:26])[OH:29])[P:14](=[O:15])([OH:18])[OH:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 54311543HCID 54311543, compound

Product 1

HCID 23184155HCID 23184155, compoundYield 53.3%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture of tetraethyl 4-phenoxybutylaminomethylenebisphosphonate (1.37 g) and concentrated hydrochloric acid (20 ml) was heated for two hours under reflux. The reaction mixture was concentrated under reduced pressure. The concentrate was treated with water to give 4-phenoxybutylaminomethylenebisphosphonic acid (0.549 g, 53%), m.p. 206° C. to 208° C.

Workup

  1. temperaturewas heated for two hours
  2. temperatureunder reflux
  3. concentrationThe reaction mixture was concentrated under reduced pressure
  4. additionThe concentrate was treated with water

Sources & evidence

ORD record
ord-36492da586f642aabdb00911ff6edd43
Source dataset
uspto-grants-1994_01
Patent number
US05280022

Reaction notes

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