HCID 131718312, compound → HCID 131718311, compound

HRID 1198123Notes

Reaction equation

HRID 1198123 reaction equation
O.O.O.[Na+:4].[Na+].[O:6]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][CH:19]([P:24](=[O:27])([O-:26])[O-:25])[P:20](=[O:23])([OH:22])[OH:21])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>O>[OH2:6].[Na+:4].[O:6]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][CH:19]([P:24](=[O:25])([OH:26])[O-:27])[P:20](=[O:21])([OH:22])[OH:23])[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1.[O:6]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][CH:19]([P:24](=[O:25])([OH:26])[O-:27])[P:20](=[O:21])([OH:22])[OH:23])[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1.[Na+:4]

Participants

3

Reactant 1

HCID 131718312HCID 131718312, compound

Product 1

HCID 131718311HCID 131718311, compoundYield 102.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5-Phenoxypentylaminomethylenebisphosphonic acid disodium salt trihydrate (1.0 g) was dissolved in water (5 ml). The solution was processed with a column of CG-50 (H type, 32 ml). The solid matter obtained from the acidic portion eluted with water was recrystallized from water-methanol to afford 5-phenoxypentylaminomethylenebisphosphonic acid monosodium salt hemihydrate (0.58 g, 68%) as colourless prisms, m.p.>300° C.

Workup

  1. customThe solid matter obtained from the acidic portion
  2. washeluted with water
  3. customwas recrystallized from water-methanol

Sources & evidence

ORD record
ord-bd0aa27e03a84680a454ecab6fc559f2
Source dataset
uspto-grants-1994_01
Patent number
US05280022

Reaction notes

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