HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 5-Chloro-6-(1-chloroethyl)-4-[1-(4-difluoromethoxyphenyl)ethylamino]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-[4-(Difluoromethoxy)phenyl]ethan-1-amine | HCID 14230781 | — |
| Reactant | 4,5-Dichloro-6-(1-chloroethyl)pyrimidine | HCID 18982868 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 5-Chloro-6-(1-chloroethyl)-4-[1-(4-difluoromethoxyphenyl)ethylamino]pyrimidine | HCID 19103995 | — |
Reaction Steps
In 50 ml of toluene were dissolved 3.8 g of 1-(4-difluoromethoxyphenyl)ethylamine and 2.3 g of triethylamine, and to the mixture was added 3.5 g of 6-(1-chloroethyl)-4,5-dichloropyrimidine. The mixture was refluxed under heating for 5 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05280025 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-e5e69bca68994a759210296ae24cfeda |
| Source note | uspto-grants-1994_01 |