Triethylamine → 5-Chloro-6-(1-chloroethyl)-4-[1-(4-difluoromethoxyphenyl)ethylamino]pyrimidine

HRID 1198129Notes

Reaction equation

HRID 1198129 reaction equation
[F:1][CH:2]([F:13])[O:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([NH2:12])[CH3:11])=[CH:6][CH:5]=1.C(N(CC)CC)C.[Cl:21][CH:22]([C:24]1[N:29]=[CH:28][N:27]=[C:26](Cl)[C:25]=1[Cl:31])[CH3:23]>C1(C)C=CC=CC=1>[Cl:31][C:25]1[C:26]([NH:12][CH:10]([C:7]2[CH:6]=[CH:5][C:4]([O:3][CH:2]([F:13])[F:1])=[CH:9][CH:8]=2)[CH3:11])=[N:27][CH:28]=[N:29][C:24]=1[CH:22]([Cl:21])[CH3:23]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 142307811-[4-(Difluoromethoxy)phenyl]ethan-1-amineHCID 189828684,5-Dichloro-6-(1-chloroethyl)pyrimidine

Product 1

HCID 191039955-Chloro-6-(1-chloroethyl)-4-[1-(4-difluoromethoxyphenyl)ethylamino]pyrimidine

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In 50 ml of toluene were dissolved 3.8 g of 1-(4-difluoromethoxyphenyl)ethylamine and 2.3 g of triethylamine, and to the mixture was added 3.5 g of 6-(1-chloroethyl)-4,5-dichloropyrimidine. The mixture was refluxed under heating for 5 hours.

Workup

  1. temperatureThe mixture was refluxed
  2. temperatureunder heating for 5 hours

Sources & evidence

ORD record
ord-e5e69bca68994a759210296ae24cfeda
Source dataset
uspto-grants-1994_01
Patent number
US05280025

Reaction notes

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