HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 6-(1-Acetoxyethyl)-5-chloro-4-[1-(4-difluoromethoxyphenyl)ethylamino]pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Potassium Acetate | HCID 517044 | — |
| Reactant | 5-Chloro-6-(1-chloroethyl)-4-[1-(4-difluoromethoxyphenyl)ethylamino]pyrimidine | HCID 19103995 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 6-(1-Acetoxyethyl)-5-chloro-4-[1-(4-difluoromethoxyphenyl)ethylamino]pyrimidine | HCID 19103970 | — |
Reaction Steps
In 50 ml of acetic acid was dissolved 3.1 g of 5-chloro-6-(1-chloroethyl)-4-[1-(4-difluoromethoxyphenyl)ethylamino]-pyrimidine, and to the mixture were added 3.0 g of potassium acetate and 3.0 g of potassium carbonate. The mixture was refluxed under heating for 30 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05280025 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-12b43bdf2e9a4eaf9bddebf519501a57 |
| Source note | uspto-grants-1994_01 |