Potassium Carbonate → 6-(1-Acetoxyethyl)-5-chloro-4-[1-(4-difluoromethoxyphenyl)ethylamino]pyrimidine

HRID 1198130Notes

Reaction equation

HRID 1198130 reaction equation
[Cl:1][C:2]1[C:3]([NH:11][CH:12]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH:21]([F:23])[F:22])=[CH:16][CH:15]=2)[CH3:13])=[N:4][CH:5]=[N:6][C:7]=1[CH:8](Cl)[CH3:9].[C:24]([O-:27])(=[O:26])[CH3:25].[K+].C(=O)([O-])[O-].[K+].[K+]>C(O)(=O)C>[C:24]([O:27][CH:8]([C:7]1[N:6]=[CH:5][N:4]=[C:3]([NH:11][CH:12]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH:21]([F:23])[F:22])=[CH:16][CH:15]=2)[CH3:13])[C:2]=1[Cl:1])[CH3:9])(=[O:26])[CH3:25]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 517044Potassium AcetateHCID 191039955-Chloro-6-(1-chloroethyl)-4-[1-(4-difluoromethoxyphenyl)ethylamino]pyrimidine

Product 1

HCID 191039706-(1-Acetoxyethyl)-5-chloro-4-[1-(4-difluoromethoxyphenyl)ethylamino]pyrimidine

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

In 50 ml of acetic acid was dissolved 3.1 g of 5-chloro-6-(1-chloroethyl)-4-[1-(4-difluoromethoxyphenyl)ethylamino]-pyrimidine, and to the mixture were added 3.0 g of potassium acetate and 3.0 g of potassium carbonate. The mixture was refluxed under heating for 30 hours.

Workup

  1. temperatureThe mixture was refluxed
  2. temperatureunder heating for 30 hours

Sources & evidence

ORD record
ord-12b43bdf2e9a4eaf9bddebf519501a57
Source dataset
uspto-grants-1994_01
Patent number
US05280025

Reaction notes

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