(Diethylamino)sulfur trifluoride → HCID 19103976, compound

HRID 1198131Notes

Reaction equation

HRID 1198131 reaction equation
[Cl:1][C:2]1[C:3]([NH:11][CH:12]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH:21]([F:23])[F:22])=[CH:16][CH:15]=2)[CH3:13])=[N:4][CH:5]=[N:6][C:7]=1[CH:8](O)[CH3:9].C(N(S(F)(F)[F:30])CC)C>ClCCl>[Cl:1][C:2]1[C:3]([NH:11][CH:12]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH:21]([F:23])[F:22])=[CH:16][CH:15]=2)[CH3:13])=[N:4][CH:5]=[N:6][C:7]=1[CH:8]([F:30])[CH3:9]

Participants

4

Reactant 2

HCID 123472(Diethylamino)sulfur trifluorideHCID 19103983HCID 19103983, compound

Product 1

HCID 19103976HCID 19103976, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In 30 ml of dichloromethane was dissolved 1.0 g of 5-chloro-6-(1-hydroxyethyl)-4-[1-(4-difluoromethoxyphenyl)-ethylamino]pyrimidine, and to the mixture was added dropwise 0.4 g of diethylaminosulfur trifluoride under ice cooling. The mixture was stirred at room temperature for 1 hour.

Sources & evidence

ORD record
ord-cf42cba7616246ed8eacaab91057ac9b
Source dataset
uspto-grants-1994_01
Patent number
US05280025

Reaction notes

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