HRID119821

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID813

Potassium cation

K+

HCID8028

Tetrahydrofuran

C4H8O

HCID97452

p-Anisyl(2-pyridyl)amine

C13H14N2O

HCID4574913

未命名化合物

HCID59624495

8-Bromo-6-chloro-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamide

C12H6BrClFN5O

HCID59624549

6,8-Dichloro-N-(3-fluoropyridin-4-yl)imidazo[1,2-b]pyridazine-3-carboxamide

C12H6Cl2FN5O

PRODUCTS

生成物

结构：COc1ccc(CN(c2ccccn2)c2cc(Cl)nn3c(C(=O)Nc4ccncc4F)cnc23)cc1

HCID59624678

6-Chloro-N-(3-fluoro-4-pyridinyl)-8-[[(4-methoxyphenyl)methyl]-2-pyridinylamino]imidazo[1,2-b]pyridazine-3-carboxamide

C25H19ClFN7O2

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-25ae55a3bdaa4a59b42972d6cb627fa8
来源数据集: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D
来源说明: Training data from https://doi.org/10.1039/C8SC04228D (2/10)

反应 SMILES

[Br:22][c:23]1[c:24]2[n:25]([c:26]([C:27]([NH:28][c:29]3[cH:30][cH:31][n:32][cH:33][c:34]3[F:35])=[O:36])[cH:37][n:38]2)[n:39][c:40]([Cl:41])[cH:42]1.[CH2:65]1[O:66][CH2:67][CH2:68][CH2:69]1.[CH3:43][O:44][c:45]1[cH:46][cH:47][c:48]([CH2:49][NH:50][c:51]2[n:52][cH:53][cH:54][cH:55][cH:56]2)[cH:57][cH:58]1.[CH3:59][C:60]([CH3:61])([O-:62])[CH3:63].[Cl:1][c:2]1[cH:3][c:4]([Cl:21])[c:5]2[n:6]([n:7]1)[c:8]([C:11](=[O:12])[NH:13][c:14]1[c:15]([F:20])[cH:16][n:17][cH:18][cH:19]1)[cH:9][n:10]2.[K+:64]>>[Cl:1][c:2]1[cH:3][c:4]([N:50]([CH2:49][c:48]2[cH:47][cH:46][c:45]([O:44][CH3:43])[cH:58][cH:57]2)[c:51]2[n:52][cH:53][cH:54][cH:55][cH:56]2)[c:5]2[n:6]([n:7]1)[c:8]([C:11](=[O:12])[NH:13][c:14]1[c:15]([F:20])[cH:16][n:17][cH:18][cH:19]1)[cH:9][n:10]2