HCID 67596106, compound → 4-{2-[2-(Dimethylamino)ethoxy]-1-hydroxyethyl}phenol--hydrogen chloride (1/1)

HRID 1198233Notes

Reaction equation

HRID 1198233 reaction equation
[ClH:1].C([O:9][C:10]1[CH:15]=[CH:14][C:13]([CH:16]([OH:24])[CH2:17][O:18][CH2:19][CH2:20][N:21]([CH3:23])[CH3:22])=[CH:12][CH:11]=1)C1C=CC=CC=1>[C].[Pd].CO>[ClH:1].[OH:9][C:10]1[CH:11]=[CH:12][C:13]([CH:16]([OH:24])[CH2:17][O:18][CH2:19][CH2:20][N:21]([CH3:22])[CH3:23])=[CH:14][CH:15]=1

Participants

4

Reactant 1

HCID 67596106HCID 67596106, compound

Product 1

HCID 30766164-{2-[2-(Dimethylamino)ethoxy]-1-hydroxyethyl}phenol--hydrogen chloride (1/1)Yield 94.1%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalyst2×HCID 887MethanolSolvent

Procedure

A mixture of 2.0 g of 1-(4-benzyloxyphenyl)-2-[2-(N,N-dimethylamino)ethoxy]ethanol hydrochloride, 500 mg of 10% palladium-carbon and 10 ml of methanol was subjected to hydrogenation for 2 hours at room temperature under atmospheric pressure. After the completion of the reaction, palladium-carbon was removed by filtration. The solvent was removed by distillation under reduced pressure to obtain 1.4 g of 1-(4-hydroxyphenyl)-2-[2-(N,N-dimethylamino)ethoxy]ethanol hydrochloride (Compound No. 170).

Workup

  1. customwas removed by filtration
  2. customThe solvent was removed by distillation under reduced pressure

Sources & evidence

ORD record
ord-03f7ff3cf91f47619fd4eef514a97c27
Source dataset
uspto-grants-1994_01
Patent number
US05280032

Reaction notes

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