HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 67596106, compound → 4-{2-[2-(Dimethylamino)ethoxy]-1-hydroxyethyl}phenol--hydrogen chloride (1/1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 67596106 | HCID 67596106 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-{2-[2-(Dimethylamino)ethoxy]-1-hydroxyethyl}phenol--hydrogen chloride (1/1) | HCID 3076616 | 94.1% |
Reaction Steps
A mixture of 2.0 g of 1-(4-benzyloxyphenyl)-2-[2-(N,N-dimethylamino)ethoxy]ethanol hydrochloride, 500 mg of 10% palladium-carbon and 10 ml of methanol was subjected to hydrogenation for 2 hours at room temperature under atmospheric pressure. After the completion of the reaction, palladium-carbon was removed by filtration. The solvent was removed by distillation under reduced pressure to obtain 1.4 g of 1-(4-hydroxyphenyl)-2-[2-(N,N-dimethylamino)ethoxy]ethanol hydrochloride (Compound No. 170).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05280032 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-03f7ff3cf91f47619fd4eef514a97c27 |
| Source note | uspto-grants-1994_01 |