HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1198317Generated: October 28, 2026
hydroxylamine-O-sulfonic acid → 4-Ethoxy-2,3-difluorobenzonitrile
https://huagongshe.com/reaction/1198317
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | hydroxylamine-O-sulfonic acid | HCID 76284 | — |
| Reactant | 4-Ethoxy-2,3-difluorobenzaldehyde | HCID 14495625 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-Ethoxy-2,3-difluorobenzonitrile | HCID 14495626 | — |
Reaction Steps
A mixture of 0.12 mol of hydroxylamine-O-sulfonic acid and 50 ml of water is added to a mixture of 0.1 mol of 4-ethoxy-2,3-difluorobenzaldehyde and 100 ml of water at 30° C. and the mixture is stirred for 1 hour. After heating at 65° C. for 2 hours and customary working up, the nitrile is obtained as a colourless solid, mp. 45° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05279764 |
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| Source dataset | uspto-grants-1994_01 |
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| ORD ID | ord-913c41f7968047d2aed28a2aa3f7f57e |
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| Source note | uspto-grants-1994_01 |
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