hydroxylamine-O-sulfonic acid → 4-Ethoxy-2,3-difluorobenzonitrile
Reaction equation
[NH2:1]OS(O)(=O)=O.[CH2:7]([O:9][C:10]1[CH:17]=[CH:16][C:13]([CH:14]=O)=[C:12]([F:18])[C:11]=1[F:19])[CH3:8]>O>[CH2:7]([O:9][C:10]1[CH:17]=[CH:16][C:13]([C:14]#[N:1])=[C:12]([F:18])[C:11]=1[F:19])[CH3:8]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 65 °C
Procedure
A mixture of 0.12 mol of hydroxylamine-O-sulfonic acid and 50 ml of water is added to a mixture of 0.1 mol of 4-ethoxy-2,3-difluorobenzaldehyde and 100 ml of water at 30° C. and the mixture is stirred for 1 hour. After heating at 65° C. for 2 hours and customary working up, the nitrile is obtained as a colourless solid, mp. 45° C.
Sources & evidence
- ORD record
- ord-913c41f7968047d2aed28a2aa3f7f57e
- Source dataset
- uspto-grants-1994_01
- Patent number
- US05279764
Reaction notes
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