反应详情

0.1 mol of 2-fluoro-4-butyloxybenzoic acid (prepared from 3-fluoro-4-cyanophenol by alkylation with butyl bromide/potassium carbonate in dimethylformamide and subsequent hydrolysis of the nitrile via the imido ester), 0.01 mol of dimethylaminopyridine and 0.1 mol of 2,3-difluoro-4-octylphenol are initially introduced into 150 ml of methylene chloride, a solution of 0.1 mol of dicyclohexylcarbodiimide in 30 ml of methylene chloride is added dropwise at 10°, while stirring, and the mixture is then subsequently stirred at room temperature for 15 hours. The mixture is filtered over silica gel and the solvent is evaporated to give 2,3-difluoro-4-octylphenyl 2-fluoro-4-butyloxybenzoate as the residue.

1. stirringthe mixture is then subsequently stirred at room temperature for 15 hours
2. filtrationThe mixture is filtered over silica gel
3. customthe solvent is evaporated