Dicyclohexylcarbodiimide → HCID 178442660, compound

HRID 1198324Notes

Reaction equation

HRID 1198324 reaction equation
[CH2:1]([C:9]1[CH:14]=[CH:13][C:12]([OH:15])=[C:11]([F:16])[C:10]=1[F:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].[CH2:18]([C@H:22]1[CH2:27][CH2:26][C@H:25]([C:28](O)=[O:29])[CH2:24][CH2:23]1)[CH2:19][CH2:20][CH3:21].C1(N=C=NC2CCCCC2)CCCCC1>CN(C)C1C=CN=CC=1.C(Cl)Cl>[CH2:18]([C@H:22]1[CH2:23][CH2:24][C@H:25]([C:28]([O:15][C:12]2[CH:13]=[CH:14][C:9]([CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8])=[C:10]([F:17])[C:11]=2[F:16])=[O:29])[CH2:26][CH2:27]1)[CH2:19][CH2:20][CH3:21]

Participants

6

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 144956302,3-Difluoro-4-octylphenolHCID 178445662HCID 178445662, compound

Product 1

HCID 178442660HCID 178442660, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent2×

Procedure

0.1 mol of this phenol, 0.1 mol of trans-4-butylcyclohexanecarboxylic acid and 0.01 mol of 4-dimethylaminopyridine are initially introduced into 150 ml of methylene chloride, a solution of 0.1 mol of dicyclohexylcarbodiimide in 30 ml of methylene chloride is added dropwise at 10°, while stirring, and the mixture is then subsequently stirred at room temperature for 15 hours. The mixture is filtered over silica gel with suction and the solvent is evaporated off to give 2,3-difluoro-4-octylphenyl trans-4-butylcyclohexanoate as the residue.

Workup

  1. stirringthe mixture is then subsequently stirred at room temperature for 15 hours
  2. filtrationThe mixture is filtered over silica gel with suction
  3. customthe solvent is evaporated off

Sources & evidence

ORD record
ord-9d5f9248f2d249cfab80d6575e3621ca
Source dataset
uspto-grants-1994_01
Patent number
US05279764

Reaction notes

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