反应详情

0.1 mol of this phenol, 0.1 mol of trans-4-butylcyclohexanecarboxylic acid and 0.01 mol of 4-dimethylaminopyridine are initially introduced into 150 ml of methylene chloride, a solution of 0.1 mol of dicyclohexylcarbodiimide in 30 ml of methylene chloride is added dropwise at 10°, while stirring, and the mixture is then subsequently stirred at room temperature for 15 hours. The mixture is filtered over silica gel with suction and the solvent is evaporated off to give 2,3-difluoro-4-octylphenyl trans-4-butylcyclohexanoate as the residue.

1. stirringthe mixture is then subsequently stirred at room temperature for 15 hours
2. filtrationThe mixture is filtered over silica gel with suction
3. customthe solvent is evaporated off