4-[(4-Ethoxy-2,3-difluorophenyl)ethynyl]-4'-propyl-1,1'-biphenyl → HCID 19103549, compound

HRID 1198336Notes

Reaction equation

HRID 1198336 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]#[C:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:23]=[CH:22][C:21]([CH2:24][CH2:25][CH3:26])=[CH:20][CH:19]=3)=[CH:14][CH:13]=2)=[C:6]([F:27])[C:5]=1[F:28])[CH3:2]>C1COCC1.[Pd]>[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]3[CH:19]=[CH:20][C:21]([CH2:24][CH2:25][CH3:26])=[CH:22][CH:23]=3)=[CH:14][CH:13]=2)=[C:6]([F:27])[C:5]=1[F:28])[CH3:2]

Participants

4

Reactant 1

HCID 678645704-[(4-Ethoxy-2,3-difluorophenyl)ethynyl]-4'-propyl-1,1'-biphenyl

Product 1

HCID 19103549HCID 19103549, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

0.031 mol of this ethine-derivative and 3 g of Pd-C (5%) are suspended in 100 ml of THF and hydrogenated at room-temperature under a hydrogen pressure of 1 bar. Customary working up gives 1-(4-ethoxy-2,3-difluorophenyl)-2-(4'-propylbiphenyl-4-yl)-ethane.

Sources & evidence

ORD record
ord-6cce4de59f7a4117822604e93b958fe0
Source dataset
uspto-grants-1994_01
Patent number
US05279764

Reaction notes

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