反应详情

To a stirred solution of 1-[(phenylmethoxy)acetyl]-4-(3-phenylpropionyl)piperazine (193 g) in tetrahydrofuran (967 ml) under a nitrogen atmosphere, was added a molar solution of borane-tetrahydrofuran complex solution in tetrahydrofuran (2.4 l) and the mixture was refluxed for 1 h. The residual borane reagent was destroyed by dropwise addition of 5N hydrochloric acid solution (430 ml) and the tetrahydrofuran was removed by distillation. The cooled reaction mixture was basified with sodium hydroxide solution, the product was extracted with ethyl acetate, and the solvents were evaporated in vacuo, after which 1-[2-(phenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (178 g) was obtained.

1. temperaturethe mixture was refluxed for 1 h
2. customThe residual borane reagent was destroyed by dropwise addition of 5N hydrochloric acid solution (430 ml)
3. customthe tetrahydrofuran was removed by distillation
4. customThe cooled reaction mixture
5. extractionthe product was extracted with ethyl acetate
6. customthe solvents were evaporated in vacuo