Methanol → HCID 86747530, compound

HRID 1198494Notes

Reaction equation

HRID 1198494 reaction equation
[CH3:1][N:2]1[C@H:6]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:5][O:4][C:3]1=[O:14].[C:15]([CH2:17][CH2:18][C@H:19]([CH2:23][C:24]([O-:26])=[O:25])[C:20]([O-:22])=[O:21])#[N:16].CO>O=[Pt]=O.C(Cl)(Cl)Cl>[CH3:1][N:2]1[C@H:6]([CH2:7][C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:5][O:4][C:3]1=[O:14].[NH2:16][CH2:15][CH2:17][CH2:18][C@H:19]([CH2:23][C:24]([O-:26])=[O:25])[C:20]([O-:22])=[O:21]

Participants

5

Reactant 2

HCID 887MethanolHCID 86747531HCID 86747531, compound

Product 1

HCID 86747530HCID 86747530, compound

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 6212ChloroformSolvent

Procedure

A mixture of 71 (2.0 g, 5.8 mmol), PtO2 (0.8 g), CH3OH (50 mL), and CHCl3 (5 mL) were shaken on the Parr apparatus under a hydrogen atmosphere (60 PSI) at ambient temperature for 3 hours. The reaction mixture was filtered through a celite pad and then concentrated to furnish the crude amine HCl 72 as a yellow oil.

Workup

  1. filtrationThe reaction mixture was filtered through a celite pad
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-16d2690258084bb9909f54abe4376dbb
Source dataset
uspto-grants-1994_01
Patent number
US05281585

Reaction notes

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