Acetyl-beta-alanine tert-butyl ester → N-Acetyl-beta-alanine

HRID 1198500Notes

Reaction equation

HRID 1198500 reaction equation
C([O:5][C:6](=[O:13])[CH2:7][CH2:8][NH:9][C:10](=[O:12])[CH3:11])(C)(C)C.C(O)C.O.[NH4+].[OH-]>>[C:10]([NH:9][CH2:8][CH2:7][C:6]([OH:13])=[O:5])(=[O:12])[CH3:11]

Participants

3

Reactant 2

HCID 19102537Acetyl-beta-alanine tert-butyl esterHCID 86596525Ethanol ammonium hydroxide water

Product 1

HCID 76406N-Acetyl-beta-alanineYield 116.4%

Procedure

Utilizing the procedure for converting 40a to 41a, 127 (0.10 g, 0.19 mmol) gave 128 (29 mg, 39%) as a fluffy solid after flash chromotography (silica, 10:1.2:1.2 ethanol/H2O/NH4OH).

Sources & evidence

ORD record
ord-5c03653d43c04599bcc91a5a20e574d6
Source dataset
uspto-grants-1994_01
Patent number
US05281585

Reaction notes

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