Phenyl isocyanate → HCID 19102696, compound

HRID 1198509Notes

Reaction equation

HRID 1198509 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]3[NH:14][C:13]4[CH2:15][CH2:16][NH:17][CH2:18][C:12]=4[C:7]=3[CH:8]=[N:9]2)=[CH:4][CH:3]=1.[C:19]1([N:25]=[C:26]=[O:27])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>O1CCCC1>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]3[NH:14][C:13]4[CH2:15][CH2:16][N:17]([C:26]([NH:25][C:19]5[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=5)=[O:27])[CH2:18][C:12]=4[C:7]=3[CH:8]=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 7672Phenyl isocyanateHCID 14069786HCID 14069786, compound

Product 1

HCID 19102696HCID 19102696, compoundYield 68%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 0.35 g (1.4 mmol) of 3-chloro-8,9,10,11-tetrahydro-7H-pyrido[3',4':4,5]pyrrolo[3,2-c]quinoline 0.185 (1.6 mmol) of phenylisocyanate and 10 ml of tetrahydrofuran is stirred at room temperature for 3 days. The reaction mixture is filtered and the solid collected is triturated in ether to yield 0.35 g (68%) of the title compound as an off white solid: m.p.>260° C.; m/e 299.

Workup

  1. filtrationThe reaction mixture is filtered
  2. customthe solid collected
  3. customis triturated in ether

Sources & evidence

ORD record
ord-d108fc7080ca4d2ba0b72f20942d8303
Source dataset
uspto-grants-1994_01
Patent number
US05281608

Reaction notes

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