2-Thiophenesulfonyl chloride → HCID 19102704, compound

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Reaction Steps

The same reaction procedure is followed as for the compound of Example 8, using 0.50 g (1.94 mmol) of 3-chloro-8,9,10,11-tetrahydro-7H-pyrido [3',4':4,5]pyrrolo[3,2-c]quinoline and 0.354 g (1.94 mmol) of 2-thiophenesulfonyl chloride. The reaction solution is diluted with water and is stirred for 2 hours. The resulting precipitate is collected by filtration and triturated with methanol/chloroform/hexane to yield 0.575 g (78%) of the title compound as an off white solid: m.p.>250° C.; m/e 403.

Provenance & Evidence