2-Thiophenesulfonyl chloride → HCID 19102704, compound

HRID 1198512Notes

Reaction equation

HRID 1198512 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]3[NH:14][C:13]4[CH2:15][CH2:16][NH:17][CH2:18][C:12]=4[C:7]=3[CH:8]=[N:9]2)=[CH:4][CH:3]=1.[S:19]1[CH:23]=[CH:22][CH:21]=[C:20]1[S:24](Cl)(=[O:26])=[O:25]>O>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]3[NH:14][C:13]4[CH2:15][CH2:16][N:17]([S:24]([C:20]5[S:19][CH:23]=[CH:22][CH:21]=5)(=[O:26])=[O:25])[CH2:18][C:12]=4[C:7]=3[CH:8]=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 855182-Thiophenesulfonyl chlorideHCID 14069786HCID 14069786, compound

Product 1

HCID 19102704HCID 19102704, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The same reaction procedure is followed as for the compound of Example 8, using 0.50 g (1.94 mmol) of 3-chloro-8,9,10,11-tetrahydro-7H-pyrido [3',4':4,5]pyrrolo[3,2-c]quinoline and 0.354 g (1.94 mmol) of 2-thiophenesulfonyl chloride. The reaction solution is diluted with water and is stirred for 2 hours. The resulting precipitate is collected by filtration and triturated with methanol/chloroform/hexane to yield 0.575 g (78%) of the title compound as an off white solid: m.p.>250° C.; m/e 403.

Workup

  1. customThe same reaction procedure
  2. filtrationThe resulting precipitate is collected by filtration
  3. customtriturated with methanol/chloroform/hexane

Sources & evidence

ORD record
ord-c17752ccaae24656a10abb4756cff0a3
Source dataset
uspto-grants-1994_01
Patent number
US05281608

Reaction notes

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