Hydrazine hydrate (1:1) → HCID 178434198, compound

HRID 1198514Notes

Reaction equation

HRID 1198514 reaction equation
[C:1]([C:4]1[C:5](=[O:21])[N:6]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:7]2[C:12]([C:13]=1O)=[CH:11][CH:10]=[CH:9][N:8]=2)(=O)[CH3:2].O.[NH2:23][NH2:24]>C(O)(=O)C>[CH3:2][C:1]1[C:4]2[C:5](=[O:21])[N:6]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[C:7]3[N:8]=[CH:9][CH:10]=[CH:11][C:12]=3[C:13]=2[NH:24][N:23]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 54715706HCID 54715706, compound

Product 1

HCID 178434198HCID 178434198, compoundYield 44.3%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Compound 102 in an amount of 1.2 g (4.3 millimoles) was suspended in 10 ml of glacial acetic acid, and 0.46 ml (9.4 millimoles) of hydrazine monohydrate was added to the suspension. Thereafter, the mixture was heated under reflux for 3 hours. The reaction solution was cooled to room temperature, and the precipitate was collected by filtration and recrystallized from DMF-water to give 530 mg (yield: 44.3%) of Compound 2.

Workup

  1. temperatureThereafter, the mixture was heated
  2. temperatureunder reflux for 3 hours
  3. filtrationthe precipitate was collected by filtration
  4. customrecrystallized from DMF-water

Sources & evidence

ORD record
ord-c123abba0f7c4996a654742da60885b4
Source dataset
uspto-grants-1994_01
Patent number
US05281610

Reaction notes

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