反应详情

Solid lithium aluminum hydride (1.0 g) was added in portions over 1 hour to a stirred solution of methyl 7-indolecarboxylate (6.7 g) in tetrahydrofuran (100 ml). The mixture was stirred for a further 2 hours then excess lithium aluminium hydride was destroyed by addition of acetic acid, the mixture was diluted with aqueous sodium hydroxide and extracted with ethyl acetate. The extract was dried and evaporated and the residue was chromatographed on silica in ethyl acetate-hexane (1:9 to 1:2) to give the product.

1. customexcess lithium aluminium hydride was destroyed by addition of acetic acid
2. additionthe mixture was diluted with aqueous sodium hydroxide
3. extractionextracted with ethyl acetate
4. customThe extract was dried
5. customevaporated
6. customthe residue was chromatographed on silica in ethyl acetate-hexane (1:9 to 1:2)
7. customto give the product