反应详情

2-Nitrophenol (11.0 g, 79 mmole), anhydrous potassium carbonate (17.6 g, 127.4 mmole) and benzhydryl bromide (19.6 g, 79 mmol) in acetone (220 ml) were refluxed under nitrogen for 5 hours. The mixture was cooled, filtered and evaporated in vacuo. The residue was triturated with diethyl ether, filtered and evaporated. Trituration with 60°-80° C. petroleum ether yielded a brown solid.

1. temperatureThe mixture was cooled
2. filtrationfiltered
3. customevaporated in vacuo
4. customThe residue was triturated with diethyl ether
5. filtrationfiltered
6. customevaporated
7. customTrituration with 60°-80° C. petroleum ether yielded a brown solid