反应详情

温度

0 °C

3-[2(E)-(7-Chloroquinolin-2-yl)ethenyl}benzaldehyde (Example 6a part i) (2.44 g, 8.3 mmol) in dry THF (75 ml) was cooled in an ice bath under nitrogen and stirred as 1M methyl magnesium iodide in diethyl ether (9.9 ml) was added over 5 minutes. The reaction was stirred at 0° C. for half an hour, warmed to room temperature and quenched with water. The mixture was extracted into ethyl acetate, the combined organic extracts dried, filtered and evaporated in vacuo.

1. additionwas added over 5 minutes
2. temperaturewarmed to room temperature
3. customquenched with water
4. extractionThe mixture was extracted into ethyl acetate
5. customthe combined organic extracts dried
6. filtrationfiltered
7. customevaporated in vacuo