Sodium Hydroxide → HCID 19102872, compound

HRID 1198616Notes

Reaction equation

HRID 1198616 reaction equation
[CH2:1]([C:5]1[N:9]([CH2:10][C:11]2[CH:16]=[CH:15][C:14]([C:17]3[C:18]([C:23]([O:25]C)=[O:24])=[CH:19][CH:20]=[CH:21][CH:22]=3)=[CH:13][CH:12]=2)[C:8]2[CH:27]=[CH:28][C:29](=[O:32])[CH:30]=[CH:31][C:7]=2[N:6]=1)[CH2:2][CH2:3][CH3:4].[OH-].[Na+]>C(O)C>[CH2:1]([C:5]1[N:9]([CH2:10][C:11]2[CH:12]=[CH:13][C:14]([C:17]3[C:18]([C:23]([OH:25])=[O:24])=[CH:19][CH:20]=[CH:21][CH:22]=3)=[CH:15][CH:16]=2)[C:8]2[CH:27]=[CH:28][C:29](=[O:32])[CH:30]=[CH:31][C:7]=2[N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86747534HCID 86747534, compound

Product 1

HCID 19102872HCID 19102872, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

An aliquot of the methyl ester from Step (n) (200 mg) was hydrolyzed by stirring it in a mixture of 5 ml of 10° sodium hydroxide and 5 ml ethanol for 4 hr at 25° C. and 1 hr at 100° C. The azeotrope was distilled off, water (10 ml) was added and the resulting solution slowly acidified to pH 2.5 with 2N HCl. The resulting precipitated acid was isolated (60 mg).

Workup

  1. custom1 hr
  2. customat 100° C
  3. distillationThe azeotrope was distilled off
  4. additionwater (10 ml) was added
  5. customThe resulting precipitated acid
  6. customwas isolated (60 mg)

Sources & evidence

ORD record
ord-7e2d6b81a75c481291abd9c1ce51cf31
Source dataset
uspto-grants-1994_01
Patent number
US05281615

Reaction notes

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