Hydrochloric Acid → HCID 13632831, compound

Participants

Reaction Conditions

Reaction Steps

5.0 kg 3-cyano-2-morpholino-5-(pyrid-4-yl)-pyridine is mixed with 25 l water and 2.0 l technical grade hydrochloric acid and is then heated to about 50° C. 3.01 hydrochloric acid is added to the yellow solution, which is then cooled. After crystallization, stirring is continued for a further 2 hours at temperatures below 20° C. The crystalline material is centrifuged off and washed with a mixture of 5.4 l water and 0.6 l hydrochloric acid. The yield is 5.3 kg (88% of the theoretical yield).

Provenance & Evidence