Hydrochloric Acid → HCID 13632831, compound
Reaction equation
[C:1]([C:3]1[C:4]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[N:5][CH:6]=[C:7]([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[CH:8]=1)#[N:2].[ClH:21]>O>[OH2:18].[ClH:21].[C:1]([C:3]1[C:4]([N:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[N:5][CH:6]=[C:7]([C:9]2[CH:10]=[CH:11][N:12]=[CH:13][CH:14]=2)[CH:8]=1)#[N:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 50 °C
Procedure
5.0 kg 3-cyano-2-morpholino-5-(pyrid-4-yl)-pyridine is mixed with 25 l water and 2.0 l technical grade hydrochloric acid and is then heated to about 50° C. 3.01 hydrochloric acid is added to the yellow solution, which is then cooled. After crystallization, stirring is continued for a further 2 hours at temperatures below 20° C. The crystalline material is centrifuged off and washed with a mixture of 5.4 l water and 0.6 l hydrochloric acid. The yield is 5.3 kg (88% of the theoretical yield).
Workup
- temperatureis then cooled
- customAfter crystallization
- washwashed with a mixture of 5.4 l water and 0.6 l hydrochloric acid
- customThe yield is 5.3 kg (88% of the theoretical yield)
Sources & evidence
- ORD record
- ord-9201798980c840e096b40697b94cc4fe
- Source dataset
- uspto-grants-1994_01
- Patent number
- US05281705
Reaction notes
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