Lipoic acid → HCID 131718320, compound

HRID 1198744Notes

Reaction equation

HRID 1198744 reaction equation
[CH2:1]1[C@@H:5]([CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])[S:4][S:3][CH2:2]1.[C:13]1([CH:19]([NH2:26])[C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>CCOCC>[CH2:1]1[C@@H:5]([CH2:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11])[S:4][S:3][CH2:2]1.[C:13]1([CH:19]([NH2:26])[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 6112Lipoic acidHCID 7036Benzhydrylamine

Product 1

HCID 131718320HCID 131718320, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

135 mg (0.654 mmol) of the R-alpha-lipoic acid so obtained were dissolved in 1 ml ether and reacted with the solution of 152 mg (0.83 mmol) diphenylmethylamine in 3.5 ml ether. The precipitate was recrystallized from methanol (1 ml) diisopropyl ether (5 ml). R-alpha-lipoic acid-diphenylmethylamine salt was obtained with a melting point of 120° C., alphaD20 =+51° (c=0.3; pyridine).

Workup

  1. customThe precipitate was recrystallized from methanol (1 ml) diisopropyl ether (5 ml)

Sources & evidence

ORD record
ord-67a95581a58944deae16d0060ee281b5
Source dataset
uspto-grants-1994_01
Patent number
US05281722

Reaction notes

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