反应详情

3.03 g (0.01 mol) of aminomethylenediphosphonic acid tetraethyl ester, 2.3 g (0.01 mol) of 3-phenoxypropylbromide and 1.4 g (0.01 mol) of potassium carbonate are dissolved in 50 ml of dioxane and stirred under reflux for 24 hours. The major part of the solvent is distilled off, and the residue is partitioned between water and ethyl acetate. The organic layer is separated, washed with water, dried over sodium sulphate and evaporated to dryness yielding raw N-(3-phenoxypropyl)aminomethanediphosphonic acid tetraethyl ester which may be used without further purification.

1. temperatureunder reflux for 24 hours
2. distillationThe major part of the solvent is distilled off
3. customthe residue is partitioned between water and ethyl acetate
4. customThe organic layer is separated
5. washwashed with water
6. dry with materialdried over sodium sulphate
7. customevaporated to dryness