Hydrochloric Acid → HCID 10154248, compound

A mixture of 520 mg (2.6 mmol) of ethyl P-(3-aminopropyl)-P-difluoromethyl-phosphinate and 5 ml of 12M hydrochloric acid is refluxed for 3 hours and then evaporated to dryness. The residue is dissolved in 5 ml of methanol. To the stirred solution 25 ml of epoxypropane are added dropwise, upon which spontaneous crystallisation occurs. The crystals are collected and dried yielding P-(3-aminopropyl)-P-difluoromethyl-phosphinic acid of m.p. 261°.

1. temperatureis refluxed for 3 hours
2. customevaporated to dryness
3. dissolutionThe residue is dissolved in 5 ml of methanol
4. additionTo the stirred solution 25 ml of epoxypropane are added dropwise, upon which spontaneous crystallisation
5. customThe crystals are collected
6. customdried

ORD record

ord-c2911a0eb28b4d939ebe7a5c2134bf85

Source dataset

uspto-grants-1994_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05281747