反应详情

A mixture of 6 g of N-(1-propenyl)piperidine, 45 ml of of diethyl ether and 4.36 ml of triethylamine is treated dropwise while stirring and gassing with nitrogen at 0° C. within 1 hour with a solution of 8.5 g of trans-4-heptyl-1-(3-chloroacryloyl)cyclohexane in 20 ml of diethyl ether. The suspension is stirred at 0° C. for a further 1 hour and then treated with 120 ml of water and extracted three times with diethyl ether. The organic phases are washed twice with water, dried over sodium sulphate, filtered and concentrated, there being obtained N-[5-(trans-4-heptylcyclohexyl)-2-methyl-5-oxo-1,3-pentadienyl]piperidine.

1. additionis treated dropwise
2. stirringThe suspension is stirred at 0° C. for a further 1 hour
3. extractionextracted three times with diethyl ether
4. washThe organic phases are washed twice with water
5. dry with materialdried over sodium sulphate
6. filtrationfiltered
7. concentrationconcentrated