HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus pentachloride → (4-Nitrophthalimido)acetyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | 2-(5-nitro-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)acetic acid | HCID 272737 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (4-Nitrophthalimido)acetyl chloride | HCID 15100608 | 99% |
Reaction Steps
To a suspension of 2-(4-nitrophthalimido)acetic acid (58.6 g) in toluene (250 ml) was added phosphorus pentachloride (48.8 g) and the mixture was refluxed for 3 hours. After completion of the reaction, the solvent was removed under reduced pressure. By addition of hexane to the residue, the title compound (62.3 g) was obtained as light yellow sharp-pointed needles.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04898859 |
| Source dataset | uspto-grants-1990_02 |
| ORD ID | ord-c117ea93444b4ec7b7aa2202c7d355e7 |
| Source note | uspto-grants-1990_02 |