Water → HCID 610558, compound

HRID 1198984Notes

Reaction equation

HRID 1198984 reaction equation
[CH3:1][C:2]1[CH:15]=[CH:14][C:5]([C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[O:7])=[C:4]([NH2:16])[CH:3]=1.O>C(O)(=O)C.OO>[CH3:1][C:2]1[CH:15]=[CH:14][C:5]2=[C:6]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)[O:7][N:16]=[C:4]2[CH:3]=1

Participants

5

Reactant 2

HCID 962WaterHCID 786512-Amino-4-methylbenzophenone

Product 1

HCID 610558HCID 610558, compoundYield 35%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 784Hydrogen PeroxideSolvent

Procedure

A solution of 31.6 g (0.15 mole) of 4-methyl-2-aminobenzophenone in 350 ml of glacial acetic acid and 175 ml of 30% hydrogen peroxide was let stand at ambient temperature for 72 hr. The solution was poured into 3 liters of water and a solid gradually crystallized. The solid was collected by filtration, washed with water and recrystallized from 2-propanol. The precipitate was slurried in 200 ml of carbon tetrachloride and filtered. The filtrate was concentrated to yield 10.5 g (35%) of title compound, m.p. 77.78° C. after recrystallization from 2-propanol.

Workup

  1. customa solid gradually crystallized
  2. filtrationThe solid was collected by filtration
  3. washwashed with water
  4. customrecrystallized from 2-propanol
  5. filtrationfiltered
  6. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-ee7f8550da5a41799ac9ffb4da2ae56a
Source dataset
uspto-grants-1990_02
Patent number
US04898874

Reaction notes

Loading…