反应详情

A solution of 49 g (0.2 mole) of (2-amino-3-methylphenyl)(4-chlorophenyl)methanone, 1 liter of glacial acetic acid and 200 ml of 30% hydrogen peroxide was let stand at ambient temperature over the weekend. The mixture was heated on a steam bath for 1 hr and poured into 2.5 liters of ice water. The solid which precipitated was collected by filtration, washed with water, and recrystallized from 2-propanol and then from cyclohexane to yield 16.4 g (34%) of crystals, m.p. 134°-136° C.

1. customwas let stand at ambient temperature over the weekend
2. temperatureThe mixture was heated on a steam bath for 1 hr
3. customThe solid which precipitated
4. filtrationwas collected by filtration
5. washwashed with water
6. customrecrystallized from 2-propanol