2-Amino-3-(4-chlorobenzoyl)benzeneacetonitrile → 3-(4-Chlorophenyl)-2,1-benzisoxazole-7-acetonitrile

HRID 1199014Notes

Reaction equation

HRID 1199014 reaction equation
[NH2:1][C:2]1[C:7]([C:8](=[O:16])[C:9]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][CH:10]=2)=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:17][C:18]#[N:19].B1([O-])OO1.O.O.O.O.[Na+]>C(O)(=O)C>[Cl:15][C:12]1[CH:13]=[CH:14][C:9]([C:8]2[O:16][N:1]=[C:2]3[C:3]([CH2:17][C:18]#[N:19])=[CH:4][CH:5]=[CH:6][C:7]=23)=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 156347322-Amino-3-(4-chlorobenzoyl)benzeneacetonitrileHCID 23693097Sodium;3-oxidodioxaborirane;tetrahydrate

Product 1

HCID 156347583-(4-Chlorophenyl)-2,1-benzisoxazole-7-acetonitrile

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Following the procedure of Intermediate 59, 2-amino-3-(4-chlorobenzoyl)benzeneacetonitrile is reacted with sodium perborate tetrahydrate in acetic acid at 70° C. and thereafter mixed with ice-water to obtain the title compound.

Sources & evidence

ORD record
ord-069304c8888f4d2a9c3431eb75b18551
Source dataset
uspto-grants-1990_02
Patent number
US04898874

Reaction notes

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