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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1199014Generated: October 30, 2026

2-Amino-3-(4-chlorobenzoyl)benzeneacetonitrile → 3-(4-Chlorophenyl)-2,1-benzisoxazole-7-acetonitrile

https://huagongshe.com/reaction/1199014

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Amino-3-(4-chlorobenzoyl)benzeneacetonitrileHCID 15634732—
ReactantSodium;3-oxidodioxaborirane;tetrahydrateHCID 23693097—
SolventAcetic AcidHCID 176—
Product3-(4-Chlorophenyl)-2,1-benzisoxazole-7-acetonitrileHCID 15634758—

Reaction Steps

Following the procedure of Intermediate 59, 2-amino-3-(4-chlorobenzoyl)benzeneacetonitrile is reacted with sodium perborate tetrahydrate in acetic acid at 70° C. and thereafter mixed with ice-water to obtain the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04898874
Source datasetuspto-grants-1990_02
ORD IDord-069304c8888f4d2a9c3431eb75b18551
Source noteuspto-grants-1990_02