Pyrrolidine → HCID 19867816, compound

HRID 1199027Notes

Reaction equation

HRID 1199027 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:17][C:18](O)=[O:19])[C:5]2[C:6]([CH:16]=1)=[C:7]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[O:8][N:9]=2.[NH:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:17][C:18](=[O:19])[N:21]2[CH2:25][CH2:24][CH2:23][CH2:22]2)[C:5]2[C:6]([CH:16]=1)=[C:7]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[O:8][N:9]=2

Participants

3

Reactant 2

HCID 31268PyrrolidineHCID 14835398HCID 14835398, compound

Product 1

HCID 19867816HCID 19867816, compound

Procedure

The title compound is prepared by reacting the acid chloride of 5-chloro-3-phenyl-2,1-benzisoxazole-7-acetic acid with pyrrolidine in an aprotic solvent and washing the reaction mixture with sodium bicarbonate and isolating the product by crystallization.

Workup

  1. washwashing the reaction mixture with sodium bicarbonate
  2. customisolating the product
  3. customby crystallization

Sources & evidence

ORD record
ord-fb4e0ba3cb7a45f2a58129ff26e65271
Source dataset
uspto-grants-1990_02
Patent number
US04898874

Reaction notes

Loading…