Piperazine → HCID 19867761, compound

HRID 1199030Notes

Reaction equation

HRID 1199030 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:17][C:18]([OH:20])=O)[C:5]2[C:6]([CH:16]=1)=[C:7]([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[O:8][N:9]=2.[NH:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:17][C:18](=[O:20])[N:21]2[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]2)[C:5]2[C:6]([CH:16]=1)=[C:7]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[O:8][N:9]=2

Participants

3

Reactant 2

HCID 4837PiperazineHCID 14835398HCID 14835398, compound

Product 1

HCID 19867761HCID 19867761, compound

Procedure

The title compound is prepared by reacting the acid chloride of 5-chloro-3-phenyl-2,1-benzisoxazole-7-acetic acid with piperazine in an aprotic solvent and washing the reaction mixture with sodium bicarbonate solution.

Workup

  1. washwashing the reaction mixture with sodium bicarbonate solution

Sources & evidence

ORD record
ord-9d7ac7cc6c134b5da16e01e09bb0419e
Source dataset
uspto-grants-1990_02
Patent number
US04898874

Reaction notes

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