反应详情

温度

0 °C

An oily suspension (50% by weight; 1.8 g) of sodium hydride is added in small portions at a temperature in the region of -5° C. to a solution, maintained under an argon atmosphere, of 3-hydroxy-2-(7-methoxy-1,8-naphthyridin-2-yl)-1-isoindolinone (9.3 g) in anhydrous dimethylformamide (120 cc), and the suspension obtained is stirred for 30 minutes at a temperature in the region of 0° C. 1-Chloro-4-methyl-2-pentanone (8.1 g) is then added dropwise while the temperature is maintained at 0° C., and stirring is continued for a further 1 hour at 0° C. and then for 4 hours at a temperature in the region of 20° C. The reaction mixture is then poured into a mixture of ice (150 g) and water (350 cc), neutralized with 1N hydrochloric acid solution and extracted with dichloromethane (3×250 cc). The organic phases are combined, washed with water (4×75 cc), dried over magnesium sulphate, filtered and then concentrated to dryness under reduced pressure (2.7 kPa) at 40° C. The residue obtained is taken up with ethyl acetate (25 cc) and the insoluble product is separated by filtration, washed successively with ethyl acetate (10 cc) and diisopropyl ether (10 cc) and then discarded. The filtrate is concentrated to dryness under reduced pressure (2.7 kPa) at 40° C. The residue obtained is purified by chromatography on silica (120 g) contained in a column 3 cm in diameter [eluant: dichloromethane/methanol (98.5:1.5 by volume)]. Elution is first performed with 170 cc of solvent: the corresponding eluate is discarded; elution is then performed with 800 cc of solvent and the corresponding eluate concentrated to dryness under reduced pressure (2.7 kPa). After recrystallization of the residue in ethyl acetate, 2-(7-methoxy-1,8-naphthyridin-2-yl)-3-(4-methyl-2-oxopentyloxy)-1isoindolinone (3 g), m.p. 120° C., is obtained. 1-Chloro-4-methyl-2-pentanone may be prepared by the method described by ASINGER F., et al., Ann. Chem., 1964, 672, 156.

1. customthe suspension obtained
2. temperatureis maintained at 0° C.
3. stirringstirring
4. waitis continued for a further 1 hour at 0° C.
5. waitfor 4 hours at a temperature in the region of 20° C
6. extractionextracted with dichloromethane (3×250 cc)
7. washwashed with water (4×75 cc)
8. dry with materialdried over magnesium sulphate
9. filtrationfiltered
10. concentrationconcentrated to dryness under reduced pressure (2.7 kPa) at 40° C
11. customThe residue obtained
12. customthe insoluble product is separated by filtration
13. washwashed successively with ethyl acetate (10 cc) and diisopropyl ether (10 cc)
14. concentrationThe filtrate is concentrated to dryness under reduced pressure (2.7 kPa) at 40° C
15. customThe residue obtained
16. customis purified by chromatography on silica (120 g)
17. washElution
18. washelution
19. concentrationthe corresponding eluate concentrated to dryness under reduced pressure (2.7 kPa)
20. customAfter recrystallization of the residue in ethyl acetate