HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1199071Generated: November 3, 2026
N-(2-Aminoethyl)piperidine → 2-(4,5-Diphenyl-1H-pyrazol-1-yl)-N-[2-(piperidin-1-yl)ethyl]acetamide
https://huagongshe.com/reaction/1199071
Participants
| Role | Name | HCID | Charge |
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| Reactant | N-(2-Aminoethyl)piperidine | HCID 33944 | — |
| Reactant | 4,5-Diphenyl-1-(ethoxycarbonylmethyl)-pyrazole | HCID 14699551 | — |
| Solvent | Diisopropylethylamine | HCID 81531 | — |
| Product | 2-(4,5-Diphenyl-1H-pyrazol-1-yl)-N-[2-(piperidin-1-yl)ethyl]acetamide | HCID 14699579 | — |
Reaction Steps
A mixture of 15 g (0.049 mol) of ethyl 4,5-diphenyl-1H-pyrazole-1-acetate of example 1 and 10.2 mL (0.072 mol) of N-(2-aminoethyl)piperidine in 62 ml of diisopropylethylamine was stirred at 100° C. for 18 hr. Upon cooling and standing a solid precipitate was formed which was filtered off and recyrtallized very slowly from 250 mL of 1:3 THF-ether to yield 10.6 of 4,5-Diphenyl-N-[2-(1-piperidinyl)ethyl]-1H-pyrazole-1-acetamide mp 95°-97° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04898880 |
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| Source dataset | uspto-grants-1990_02 |
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| ORD ID | ord-9df8824b4e1246aca6dffccbd2c4dbaf |
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| Source note | uspto-grants-1990_02 |
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