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HRID1199071

反应详情

EQUATION

反应方程式

HRID 1199071 的结构方程式

REACTANTS

反应物

2
结构：NCCN1CCCCC1
HCID33944

N-(2-Aminoethyl)piperidine

C7H16N2

结构：CCOC(=O)Cn1ncc(-c2ccccc2)c1-c1ccccc1
HCID14699551

Ethyl (4,5-diphenyl-1H-pyrazol-1-yl)acetate

C19H18N2O2

PRODUCTS

生成物

1
结构：O=C(Cn1ncc(-c2ccccc2)c1-c1ccccc1)NCCN1CCCCC1
HCID14699579

2-(4,5-Diphenyl-1H-pyrazol-1-yl)-N-[2-(piperidin-1-yl)ethyl]acetamide

C24H28N4O

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCN(C(C)C)C(C)C
溶剂HCID81531

Diisopropylethylamine

C8H19N

CONDITIONS

反应条件

温度
100 °C

PROCEDURE

实验过程

A mixture of 15 g (0.049 mol) of ethyl 4,5-diphenyl-1H-pyrazole-1-acetate of example 1 and 10.2 mL (0.072 mol) of N-(2-aminoethyl)piperidine in 62 ml of diisopropylethylamine was stirred at 100° C. for 18 hr. Upon cooling and standing a solid precipitate was formed which was filtered off and recyrtallized very slowly from 250 mL of 1:3 THF-ether to yield 10.6 of 4,5-Diphenyl-N-[2-(1-piperidinyl)ethyl]-1H-pyrazole-1-acetamide mp 95°-97° C.

WORKUP

后处理

  1. temperatureUpon cooling
  2. customwas formed which
  3. filtrationwas filtered off