Isopropanol → Cefadroxil monohydrate

HRID 1199090Notes

Reaction equation

HRID 1199090 reaction equation
[CH3:1][C:2]1[CH2:22][S:21][C@@H:5]2[C@H:6]([NH:9][C:10]([C@H:12]([NH2:20])[C:13]3[CH:14]=[CH:15][C:16]([OH:19])=[CH:17][CH:18]=3)=[O:11])[C:7](=[O:8])[N:4]2[C:3]=1[C:23]([OH:25])=[O:24].C([OH:29])(C)C>O>[CH3:1][C:2]1[CH2:22][S:21][C@@H:5]2[C@H:6]([NH:9][C:10]([C@H:12]([NH2:20])[C:13]3[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=3)=[O:11])[C:7](=[O:8])[N:4]2[C:3]=1[C:23]([OH:25])=[O:24].[OH2:29]

Participants

4

Reactant 2

HCID 3776IsopropanolHCID 47965Cefadroxil

Product 1

HCID 47964Cefadroxil monohydrate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

According to such a method a cefadroxil solvate is slurried with isopropyl alcohol containing less 6% to 18% of water at a temperature between +45° to +55° C.: the crystalline cefadroxil monohydrate is isolated by filtration.

Sources & evidence

ORD record
ord-bb73c554414c4ee9a337e0ef284c3629
Source dataset
uspto-grants-1990_02
Patent number
US04898938

Reaction notes

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