Water → Cefadroxil

HRID 1199093Notes

Reaction equation

HRID 1199093 reaction equation
[CH3:1][C:2]1[CH2:22][S:21][C@@H:5]2[C@H:6]([NH:9][C:10]([C@H:12]([NH2:20])[C:13]3[CH:14]=[CH:15][C:16]([OH:19])=[CH:17][CH:18]=3)=[O:11])[C:7](=[O:8])[N:4]2[C:3]=1[C:23]([OH:25])=[O:24].CN1CCCC1=O.O>C(O)(C)C>[CH3:1][C:2]1[CH2:22][S:21][C@@H:5]2[C@H:6]([NH:9][C:10]([C@H:12]([NH2:20])[C:13]3[CH:14]=[CH:15][C:16]([OH:19])=[CH:17][CH:18]=3)=[O:11])[C:7](=[O:8])[N:4]2[C:3]=1[C:23]([OH:25])=[O:24]

Participants

4

Reactant 2

HCID 962WaterHCID 14996562HCID 14996562, compound

Product 1

HCID 47965Cefadroxil

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Cefadroxil 1-methyl-2-pyrrolidone solvate (30 g) prepared according to example 4 was slurried in isopropyl alcohol (150 ml) containing 10 ml of water at 50°-52° C. for 120'.

Sources & evidence

ORD record
ord-9a7b95bfac134f9ebcf6ef931d9e9aa5
Source dataset
uspto-grants-1990_02
Patent number
US04898938

Reaction notes

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