HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1199126Generated: November 3, 2026
Diethyl (ethoxymethylene)malonate → Diethyl (2,5-dimethyl-6-fluoro-1,2,3,4-tetrahydro-1-quinolinyl)methylenemalonate
https://huagongshe.com/reaction/1199126
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| Reactant | 6-Fluoro-2,5-dimethyl-1,2,3,4-tetrahydroquinoline | HCID 13669246 | — |
| Product | Diethyl (2,5-dimethyl-6-fluoro-1,2,3,4-tetrahydro-1-quinolinyl)methylenemalonate | HCID 13669249 | — |
Reaction Steps
3350 g (18.7 mole) of 2,5-dimethyl-6-fluoro-1,2,3,4-tetrahydroquinoline and 4445.7 g (20.6 mole) of diethyl ethoxymethylenemalonate were combined and heated to 110° C. The ethanol was removed by atmospheric distillation initially and then through vacuum distillation when the reaction temperature reached 150° C. The resulting material, diethyl (2,5-dimethyl-6-fluoro-1,2,3,4-tetrahydro-1-quinolinyl)methylenemalonate, was used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04898945 |
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| Source dataset | uspto-grants-1990_02 |
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| ORD ID | ord-2950643272044237a9a4b0526028e125 |
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| Source note | uspto-grants-1990_02 |
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