反应详情

温度

110 °C

3350 g (18.7 mole) of 2,5-dimethyl-6-fluoro-1,2,3,4-tetrahydroquinoline and 4445.7 g (20.6 mole) of diethyl ethoxymethylenemalonate were combined and heated to 110° C. The ethanol was removed by atmospheric distillation initially and then through vacuum distillation when the reaction temperature reached 150° C. The resulting material, diethyl (2,5-dimethyl-6-fluoro-1,2,3,4-tetrahydro-1-quinolinyl)methylenemalonate, was used directly in the next step.

1. customThe ethanol was removed by atmospheric distillation initially
2. distillationthrough vacuum distillation when the reaction temperature
3. customreached 150° C