Iodine → 2-Chloro-1-fluoro-4-nitrobenzene

HRID 1199258Notes

Reaction equation

[F:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.[Sb](Cl)(Cl)(Cl)(Cl)[Cl:12].II>>[Cl:12][C:3]1[CH:4]=[C:5]([N+:8]([O-:10])=[O:9])[CH:6]=[CH:7][C:2]=1[F:1]

Participants

Reactant 3

HCID 807Iodine

HCID 9590p-Fluoronitrobenzene

HCID 24294Antimony pentachloride

Product 1

HCID 676882-Chloro-1-fluoro-4-nitrobenzeneYield 99%

Procedure

141 G of 4-fluoronitrobenzene, 7 g of antimony pentachloride and 0.5 g of iodine were charged. The same succeeding procedures as in Example 1 were repeated to obtain 173 g (yield: 99%) of 3-chloro-4-fluoronitrobenzene. Analytical value thereof by gas chromatography was as follows:

Sources & evidence

ORD record: ord-9b0eb4a7d2e448afb2ac2ecfba10acd1
Source dataset: uspto-grants-1990_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04898996

Reaction notes

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