Iodine → 2-Chloro-1-fluoro-4-nitrobenzene

HRID 1199259Notes

Reaction equation

HRID 1199259 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][CH:3]=1.II.[Cl:13]Cl>>[Cl:13][C:3]1[CH:4]=[C:5]([N+:8]([O-:10])=[O:9])[CH:6]=[CH:7][C:2]=1[F:1]

Participants

4

Reactant 3

HCID 807IodineHCID 9590p-FluoronitrobenzeneHCID 24526Chlorine

Product 1

HCID 676882-Chloro-1-fluoro-4-nitrobenzene

Procedure

141 G of 4-fluoronitrobenzene, 11.5 g of ferric chloride and 0.6 g of iodine were charged and then heated. At a temperature of 50° to 55° C., 80 g of chlorine was blown into the liquid over 12 hours to complete the reaction. The same succeeding procedures as in Example 1 were repeated to obtain 174 g of 3-chloro-4-fluoronitrobenzene. Analytical value thereof by gas chromatography was as follows:

Workup

  1. temperatureheated
  2. customthe reaction

Sources & evidence

ORD record
ord-6847b57e10df478c800ef8fab96d3336
Source dataset
uspto-grants-1990_02
Patent number
US04898996

Reaction notes

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